Streptococcal collagen‐like protein 1 shields group A Streptococcus from antimicrobial molecules (836.8)
نویسندگان
چکیده
منابع مشابه
Group B Streptococcal Sepsis in a Newborn: a Case Report
Newborns’ bacterial infections due to group B Streptococcus (GBS) happen in two forms including early-onset disease or late-onset disease. In this paper, we report a case of early-onset GBS infection in a male infant. A 22-year-old primigravid woman delivers a term normal looking male infant. Nasal flaring, grunting, and poor feeding presented soon after birth. An empiric treatment wit...
متن کاملRole for streptococcal collagen-like protein 1 in M1T1 group A Streptococcus resistance to neutrophil extracellular traps.
Streptococcal collagen-like protein 1 (Scl-1) is one of the most highly expressed proteins in the invasive M1T1 serotype group A Streptococcus (GAS), a globally disseminated clone associated with higher risk of severe invasive infections. Previous studies using recombinant Scl-1 protein suggested a role in cell attachment and binding and inhibition of serum proteins. Here, we studied the contri...
متن کاملGroup A Streptococcal M1 Protein Provides Resistance against the Antimicrobial Activity of Histones
Histones are essential elements of chromatin structure and gene regulation in eukaryotes. An unexpected attribute of these nuclear proteins is their antimicrobial activity. A framework for histone release and function in host defense in vivo was revealed with the discovery of neutrophil extracellular traps, a specialized cell death process in which DNA-based structures containing histones are e...
متن کاملStreptococcal collagen-like protein A and general stress protein 24 are immunomodulating virulence factors of group A Streptococcus.
In Western countries, invasive infections caused by M1T1 serotype group A Streptococcus (GAS) are epidemiologically linked to mutations in the control of virulence regulatory 2-component operon (covRS). In indigenous communities and developing countries, severe GAS disease is associated with genetically diverse non-M1T1 GAS serotypes. Hypervirulent M1T1 covRS mutant strains arise through select...
متن کاملDefense from the Group A Streptococcus by active and passive vaccination with the streptococcal hemoprotein receptor.
BACKGROUND The worldwide burden of the Group A Streptococcus (GAS) primary infection and sequelae is considerable, although immunization programs with broad coverage of the hyper variable GAS are still missing. We evaluate the streptococcal hemoprotein receptor (Shr), a conserved streptococcal protein, as a vaccine candidate against GAS infection. METHODS Mice were immunized intraperitoneally...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2014
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.28.1_supplement.836.8